Studying fungal pathogens of humans and fungal infections: fungal diversity and diversity of approaches
نویسندگان
چکیده
منابع مشابه
Laboratory diagnosis of fungal infections
Selection of appropriate specimens for culture and microscopic examination is based on the results of clinical and radiographic examination and consideration of the most likely fungal pathogen that may cause such an infection. Specimens should be collected under aseptic conditions or after appropriate cleaning and decontamination of the collection site and rapidly transported to the clinical my...
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Background: Candida auris is a globally emerging yeast pathogen that has shown not only resistance to most anti-fungal drugs but also thermo-tolerance to temperatures higher than the mammalian’s body temperature. Although it has been only a decade since the fungus was identified, its spread of infections has been rapid and quasi-epidemics have been reported. Co-occurrences of the fungus infecti...
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Many drug discovery projects rely on commercial compounds to discover active leads. However, current commercial libraries, with mostly synthetic compounds, access a small fraction of the possible chemical diversity. Natural products, in contrast, possess a vast structural diversity and have proven to be an outstanding source of new drugs. Several chemoinformatic analyses of natural products hav...
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While fungal infections of the CNS are relatively rare, they have become more common with the increasing number of individuals who are immunocompromised due to HIV/AIDS, immunosuppressive therapies, invasive diagnosis and treatment methods, and organ transplants. CNS fungal infections present many diagnostic and therapeutic challenges and are associated with a high mortality rate. Cryptococcal ...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2019
ISSN: 1466-4879,1476-5470
DOI: 10.1038/s41435-019-0071-2